811 research outputs found
Facile one-pot synthesis of amoxicillin-coated gold nanoparticles and their antimicrobial activity
Nanomaterials have been the object of intense study due to promising applications in a number of different disciplines. In particular, medicine and biology have seen the potential of these novel materials with their nanoscale properties for use in diverse areas such as imaging, sensing and drug vectorisation. Gold nanoparticles (GNPs) are considered a very useful platform to create a valid and efficient drug delivery/carrier system due to their facile and well-studied synthesis, easy surface functionalization and biocompatibility. In the present study, stable antibiotic conjugated GNPs were synthesised by a one-step reaction using a poorly water soluble antibiotic, amoxicillin. Amoxicillin, a member of the penicillin family, reduces the chloroauric acid to form nanoparticles and at the same time coats them to afford the functionalised nanomaterial. A range of techniques including UV-vis spectroscopy, dynamic light scattering (DLS), transmission electron microscopy (TEM) and thermogravimetric analysis (TGA) were used to ascertain the gold/drug molar ratio and the optimum temperature for synthesis of uniform monodisperse particles in the ca. 30-40 nm size range. Amoxicillin-conjugated gold showed an enhancement of antibacterial activity against Escherichia coli compared to the antibiotic alone
Diffusion Limited Aggregation with Power-Law Pinning
Using stochastic conformal mapping techniques we study the patterns emerging
from Laplacian growth with a power-law decaying threshold for growth
(where is the radius of the particle cluster). For
the growth pattern is in the same universality class as diffusion
limited aggregation (DLA) growth, while for the resulting patterns
have a lower fractal dimension than a DLA cluster due to the
enhancement of growth at the hot tips of the developing pattern. Our results
indicate that a pinning transition occurs at , significantly
smaller than might be expected from the lower bound
of multifractal spectrum of DLA. This limiting case shows that the most
singular tips in the pruned cluster now correspond to those expected for a
purely one-dimensional line. Using multifractal analysis, analytic expressions
are established for both close to the breakdown of DLA universality
class, i.e., , and close to the pinning transition, i.e.,
.Comment: 5 pages, e figures, submitted to Phys. Rev.
A New Class of Majoron-Emitting Double-Beta Decays
Motivated by the excess events that have recently been found near the
endpoints of the double beta decay spectra of several elements, we re-examine
models in which double beta decay can proceed through the neutrinoless emission
of massless Nambu-Goldstone bosons (majorons). Noting that models proposed to
date for this process must fine-tune either a scalar mass or a VEV to be less
than 10 keV, we introduce a new kind of majoron which avoids this difficulty by
carrying lepton number . We analyze in detail the requirements that
models of both the conventional and our new type must satisfy if they are to
account for the observed excess events. We find: (1) the electron sum-energy
spectrum can be used to distinguish the two classes of models from one another;
(2) the decay rate for the new models depends on different nuclear matrix
elements than for ordinary majorons; and (3) all models require a (pseudo)
Dirac neutrino, having a mass of a several hundred MeV, which mixes with
.Comment: 43 pages, 10 figures (included), [figure captions are now included
Influence of Long-Range Coulomb Interactions on the Metal-Insulator Transition in One-Dimensional Strongly Correlated Electron Systems
The influence of long-range Coulomb interactions on the properties of
one-dimensional (1D) strongly correlated electron systems in vicinity of the
metal-insulator phase transition is considered. It is shown that unscreened
repulsive Coulomb forces lead to the formation of a 1D Wigner crystal in the
metallic phase and to the transformation of the square-root singularity of the
compressibility (characterizing the commensurate-incommensurate transition) to
a logarithmic singularity. The properties of the insulating (Mott) phase depend
on the character of the short-wavelength screening of the Coulomb forces. For a
sufficiently short screening length the characteristics of the charge
excitations in the insulating phase are totally determined by the Coulomb
interaction and these quasipartic les can be described as quasiclassical
Coulomb solitons.Comment: 14 pages, LaTeX, G{\"o}teborg preprint APR 94-3
Time evolution of models described by one-dimensional discrete nonlinear Schr\"odinger equation
The dynamics of models described by a one-dimensional discrete nonlinear
Schr\"odinger equation is studied. The nonlinearity in these models appears due
to the coupling of the electronic motion to optical oscillators which are
treated in adiabatic approximation. First, various sizes of nonlinear cluster
embedded in an infinite linear chain are considered. The initial excitation is
applied either at the end-site or at the middle-site of the cluster. In both
the cases we obtain two kinds of transition: (i) a cluster-trapping transition
and (ii) a self-trapping transition. The dynamics of the quasiparticle with the
end-site initial excitation are found to exhibit, (i) a sharp self-trapping
transition, (ii) an amplitude-transition in the site-probabilities and (iii)
propagating soliton-like waves in large clusters. Ballistic propagation is
observed in random nonlinear systems. The effect of nonlinear impurities on the
superdiffusive behavior of random-dimer model is also studied.Comment: 16 pages, REVTEX, 9 figures available upon request, To appear in
Physical Review
The Current-Temperature Phase Diagram of Layered Superconductors
The behavior of clean layered superconductors in the presence of a finite
electric current and in zero-magnetic field behavior is addressed. The
structure of the current temperature phase diagram and the properties of each
of the four regions will be explained. We will discuss the expected current
voltage and resistance characteristics of each region as well as the effects of
finite size and weak disorder on the phase diagram. In addition, the reason for
which a weakly non-ohmic region exists above the transition temperature will be
explained.Comment: 8 pages (RevTeX), 4 encapsulated postscript figure
The Search for Stable, Massive, Elementary Particles
In this paper we review the experimental and observational searches for
stable, massive, elementary particles other than the electron and proton. The
particles may be neutral, may have unit charge or may have fractional charge.
They may interact through the strong, electromagnetic, weak or gravitational
forces or through some unknown force. The purpose of this review is to provide
a guide for future searches - what is known, what is not known, and what appear
to be the most fruitful areas for new searches. A variety of experimental and
observational methods such as accelerator experiments, cosmic ray studies,
searches for exotic particles in bulk matter and searches using astrophysical
observations is included in this review.Comment: 34 pages, 8 eps figure
Time evolution of damage under variable ranges of load transfer
We study the time evolution of damage in a fiber bundle model in which the
range of interaction of fibers varies through an adjustable stress transfer
function recently introduced. We find that the lifetime of the material
exhibits a crossover from mean field to short range behavior as in the static
case. Numerical calculations showed that the value at which the transition
takes place depends on the system's disorder. Finally, we have performed a
microscopic analysis of the failure process. Our results confirm that the
growth dynamics of the largest crack is radically different in the two limiting
regimes of load transfer during the first stages of breaking.Comment: 8 pages, 7 figures, revtex4 styl
Principal scientific results of the Surveyor 3 Mission
The fine lunar surface material at the Surveyor 3 landing site has about 3 × 10^3-dyne/cm^2 cohesion, 35° angle of internal friction, 3 × 10^5-dyne/cm^2 static bearing capacity. A small rock withstood a local pressure of 2 × 10^7 dynes/cm^2. Soil strength and density increase significantly at depths of a few centimeters. Exposed surface has a considerably higher albedo than the material just below it. The photometric function changed when the surface was slightly compressed. Fine surface material appears to be gradually moving downslope
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